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A significant concern is that the most common adverse effects of GLP-1 agonistsnausea, vomiting, diarrhea, and abdominal painoverlap substantially with Crohn's disease symptoms

While this might be considered a secondary benefit, it also means that patients who do drink may experience exaggerated nausea or hypoglycemia, especially if meals are skipped

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real-world patient-reported rates are notably higher Typical onset: Days 3-14 after first injection, or within 2-5 days of each dose escalation Severity distribution: Predominantly mild (grade 1) to moderate (grade 2)