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In older adults, lifestyle modifications remain a significant challenge [11, 20], and the increasing burden of NCDs further underscores the strategic role of pharmacotherapy as part of a comprehensive strategy of the obesity management
This warning is not based on human epidemiology alone but largely originates from rodent toxicology studies , where GLP-1 receptor activation led to: Increased calcitonin secretion C-cell hyperplasia C-cell adenomas and carcinomas in rats/mice These findings have been consistently observed across multiple GLP-1 receptor agonists
GLP-1 agonists excel at weight reduction and cardiovascular protection, while SGLT2 inhibitors lead in renal preservation and heart failure management
Proper storage conditions maintain peptide integrity and prevent degradation that could compromise therapeutic efficacy
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