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Part B, Biochemistry & molecular biology 121, 177184 (1998)
it was an unexpectedly sunny day in mid November when I met Jrgensen at Novo headquarters
In Notable's case, the formula seems informed in part by willful ignorance, wishful thinking, or, more rarely, sound science
Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)
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