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de Gregorio D, Posa L, Ochoa-Sanchez R, McLaughlin R, Maione S, Comai S, et al
in vitro and animal studies have linked thymosin beta-4 overexpression to increased tumor size and metastasis in several cancer types (including colorectal and pancreatic cancer), leading researchers to flag a theoretical cancer-promotion risk, particularly for anyone with an active malignancy or recent cancer history Self-reported effects compiled from user and case reports, not controlled trials, include injection-site redness or itching, transient fatigue, and headache
Eur J Pediatr 2022;181:1835-57
In this study, we designed a peptide inhibitor based on the p53 transactivation domain (TAD) sequence and investigated its binding interface at the atomic level using NMR spectroscopy