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There are conditions however that, at the very least, would indicate significant quantitative differences in the sensitivity of humans to these effects, with rodents being considerably more sensitive to thyroid effects by virtue of differences in the biology, transport and control of thyroid hormones in these species as opposed to humans where turnover is appreciably lower and where serum transport of T4/T3 is different to that operating in rodents

Differentiated H9c2 cardiomyocytes were plated on a collagen-coated chamber, and the cells were stretched by 10% for 1 h (Fig

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