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Inconsistent use of some GLP-1 weight-loss medications may significantly lessen their effectiveness, according to Penn Medicine research, meaning sporadic dosing or frequent starts and stops can reduce their effectiveness over time

Ito K, Hanazawa T, Tomita K, Barnes PJ, Adcock IM: Oxidative stress reduces histone deacetylase-2 activity and enhances IL-8 gene expression: role of tyrosine nitration

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Deficiency can show up as fatigue, weakness, numbness/tingling, balance problems, memory issues, and megaloblastic anemia