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At the cellular level, thyroid hormones act through nuclear receptors TR and TR to regulate transcription of genes involved in neuronal metabolism, mitochondrial biogenesis, and cytoskeletal organization (64, 65)
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ERGO works hand-in-hand with other antioxidants to control oxidative stress in the mitochondria
However, malnutrition and starvation are difficult to assess clinically and in particular protein-calorie malnutrition can co-exist with chronic alcohol use and with inter-current acute or chronic illness, which may independently or in concert increase the risk of paracetamol toxicity and confound the assertion that malnutrition per se increases the risk of paracetamol toxicity [6, 16, 73, 78,79,80,81,82,83]
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