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10 In agreement with this observation, targeted disruption of the Gpbar1/TGR5 gene in mice favors fat accumulation with body weight gain, which is proved to be the result of decreased energy expenditure

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using a rodent model showed that one week of HFD leads to insulin resistance during a hyperinsulinemic-euglycemic clamp, impaired muscle MBF (assessed via CEU), abolished insulin-stimulated Akt and eNOS phosphorylation and increased inflammation in the aorta but not in muscle [67]

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healthcare costs related to obesity and its complications