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Current scientific consensus emphasizes that the primary criterion for probiotic selection is the specific clinical indicationwhether prophylactic, therapeutic, or adjunctivegiven the marked differences in efficacy exhibited by individual bacterial strains across distinct health objectives (517)

Supportive strategies may include: Reducing immune reactivity sets the stage for more effective detoxification and allows the gut-brain axis to begin healing

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A phase 3 study (Identifier: NCT02187003) to evaluate the efficacy and safety of rivipansel in the treatment of VOC in hospitalized patients with SCD was terminated (posted on ClinicalTrials.gov February 20, 2020) based on failure of the primary study (NCT02433158) to meet the study efficacy endpoints of time to readiness-for-discharge