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After the run-in period, those with inadequate glycemic control (A1C 6.5% to 10%) were randomized 1:1 to the addition of sitagliptin 100 mg once daily or glipizide for 52 weeks
Country of Origin: USA Manufacturer/Importer/Packed By : O Bloom Country of Origin: USA Manufacturer/Importer/Packed By : O Bloom
Side effects included nausea (39% of patients), diarrhea (25%) and vomiting (28%) [29] Overall, orfoglipron achieves comparable weight loss with other GLP1R agonists such as semaglutide and Rybelsus, but has a slightly better side effect profile and achieves weight loss in a shorter period of time
Pharmaceutical maker Novo Nordisk has said it plans to seek regulatory approval for its use in treating liver disease sometime this year
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