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518 These findings suggest that activation of the PERK-eIF2 pathway protects (re)myelinating oligodendrocytes from the harmful effects of IFN in immune-mediated demyelinating diseases
The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)
PLoS Med
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