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Introduction Making a new vaccine from scratch is a technologically challenging process
This manifests microscopically as hepatic necrosis, especially near the terminal hepatic vein, where cytochrome P450 enzymes are concentrated
Changes of 10% or more represent meaningful progress
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The potential molecular pathways that can be targeted include IL-4-IL-13-JAK-STAT-MAP kinases, adiponectin-iNOS-NF-B, PGD2-CRTH2, IFNs-RIG, Wnt/-catenin-FAM13A, FOXC1-miR-PI3K/AKT, JNK-Gal-7, Nrf2-ROS, Foxp3-RORt, CysLTR, AMP, Fas-FasL, PTHrP/PPAR, PAI-1, FcRI-LAT-SLP-76, Tim-3-Gal-9, TLRs-MyD88, PAR2, and Keap1/Nrf2/ARE
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