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Retatrutide dose levels tested in clinical trials The Phase 2 trial published in the New England Journal of Medicine tested four dose tiers against placebo over 48 weeks
Studies suggest these effects stem from weight loss, improved insulin sensitivity, and direct actions on metabolic pathways that regulate lipid production
This research brief focuses on the GLP-1 receptor agonists semaglutide and tirzepatide that are branded under multiple product names, and which were originally developed for managing type 2 diabetes
J Clin Epidemiol 66(7):719725
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