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The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized: Anaphylaxis and death Cardiovascular: Pulmonary edema and congestive cardiac/heart failure during early treatment

Better Bone Health: Adequate B12 levels are associated with higher bone mineral density

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2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Supplementary Table S1