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Lancet 400(10366):18691881 Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S et al (2023) Retatrutide phase 2 obesity trial investigators
Mit der hchsten Dosierung von 36 mg pro Tag verloren die Teilnehmenden im Durchschnitt 10,5 % ihres Krpergewichts (10,3 kg), verglichen mit 2,2 % unter Placebo
Arch Toxicol 92:169180
Previous microneedle patches for the same drug achieved only around 30% bioavailability
Adverse events leading to study discontinuation occurred in 311% of those treated with tirzepatide, 3% with placebo, 4% with semaglutide and 15% with basal insulins
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