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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations GLP-1RA, glucagon-like peptide-1 receptor agonists

As an example, in experimental conditions with animal models (GLP-1R-null), TZP reduced appetite and food intake, liver glycogenolysis and gluconeogenesis, improved insulin sensibility (assessed by euglycemic clamp) and glucose disposal in white and brown adipose tissue, skeletal muscle, with body weight-dependent and independent effects (73)

For laboratories conducting in vitro or specialized in vivo studies requiring liquid solution: Diluent: Use deionized water or a physiological saline solution for solubility

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