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A downregulated miR-145 can restrict melanocyte proliferation and cause melanocyte death by inducing apoptosis via caspase-3 and caspase-7 activation, thereby playing a prime role in disease initiation (Sahmatova et al
Experimental overexpression models also describe modulation of proteolytic regulators and ubiquitinproteasome system components, supporting its relevance in mechanistic studies of anabolic and catabolic signaling balance at the cellular level
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Computational and Theoretical Chemistry , 1227, 114227
However, unchecked chronic inflammation can lead to many different diseases
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