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Under normal circumstances, collateral vessels enlarge gradually over weeks to months in response to sustained ischemia
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In mice, the loss of JNK1 and JNK2 led to more severe age-related OA and ageing of cartilage and synovium (Loeser et al., 2020), an indication that JNK is a detrimental regulator of joint degeneration
GLP-1 receptor agonists are FDA-approved for weight loss and type 2 diabetes
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