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The curcumin and gallic acid -loaded microneedles provide immediate antioxidant and anti-inflammatory effects, alleviating AD symptoms in the short term, while the embedded PLGA needle mediates the sustained release of curcumin for long-term improvement

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Since B12 is water-soluble and any unused B12 in the body is excreted through urine, consuming more than the daily amount or taking vitamin supplements of up to 1000 mcg a day is considered safe