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This allows clear identification of which compound causes any effects
They can be expensive, and not all insurance plans provide coverage, causing patients to stop taking them
In recent years, lower doses of naltrexone have been used off-label to help with weight loss, especially when combined with other medications like bupropion
However, owing to their peptide-based composition, GLP-1RAs have traditionally required injectable administration, which undermines patient adherence, convenience, and long-term accessibility
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doi: 10.1056/NEJMoa2107519 36 LudvikBGiorginoFJdarEFriasJPFernndez LandLBrownKet al
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