2022 The major difference between these agents lies in canagliflozin, which is less selective for SGLT2 over SGLT1 and is metabolized primarily in the liver (compared to kidneys), and sotagliflozin, which inhibits both SGLT1 and SGLT2
At this time, there is no other medication like GLP-1s that consistently produces the degree of sustainable, clinically meaningful weight loss while improving metabolic markers, says Dr
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Typically, GI side effects of GLP-1s, such as nausea and vomiting, are dose-dependent, mild-to-moderate in severity, and occur mostly during initiation of therapy and up-titration
Lebrun et al