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Importantly, pharmacologically inhibiting FASN with orlistat restores ferroptotic sensitivity and synergistically enhances antitumor effects when combined with sorafenib across both in vitro and in vivo models, suggesting that targeting the FASN/HIF-1/SLC7A11 axis may overcome sorafenib resistance in HCC (256)

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02 Shot Preparation The injection site is prepped quickly, typically the upper arm or glute, for a comfortable experience

Lab tests and imaging provide direction without delaying treatment