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Anticipated uses: Obesity management (with or without diabetes) Type 2 diabetes Fatty liver disease (potentially pending NASH approval) Retatrutide vs Tirzepatide: Summary Comparison Conclusion Tirzepatide has changed the game in obesity and diabetes carebut retatrutide is poised to redefine the future of metabolic medicine

This is one reason injectable options are often discussed separately from topical products or capsules

In February 2026 , the company announced positive results from the Phase 2b VESPER-3 study investigating monthly maintenance dosing of its injectable GLP-1 receptor agonist