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The sulfonation reaction saturates at relatively modest doses, but the rates of the glucoronidation reaction and the rate of formation of NAPQI by the P450 reaction increase monotonically with dose
Finally, tirzepatide was associated with significantly reduced occurrence of a composite kidney outcome comprising new-onset MA, 40% eGFR decline, end-stage renal disease and death due to kidney failure (HR 0.58, 95% CI 0.430.80) [49]
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