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[1] [2] When intestinal transit accelerates during diarrheal episodes, the normal reabsorption of intestinal secretions decreases, and protective mucus may become more prominent

Building tolerance over the first week matters more here than accelerating results

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Nevertheless, in a network meta-analysis comparing short-acting and long-acting GLP-1RAs when used in conjunction with basal insulin, long-acting GLP-1RAs resulted in significantly greater reductions in glycated hemoglobin (HbA1c), fasting plasma glucose, and body weight compared to short-acting GLP-1RAs, with better gastrointestinal tolerability [15]

Introduction: A New Era in Obesity Treatment Obesity is no longer viewed merely as a lifestyle issue