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As the importance of R-2-HG in boosting tumor initiation, proliferation and metastasis is emphasized, identifying whether metabolic enzymes or transporters associated with glutamine metabolism could be involved in the generation of R-2-HG is interesting
Mechanisms of wound reepithelialization: hints from a tissue-engineered reconstructed skin to long-standing questions
Updates and Ongoing Progress (as of mid-2026) The FORWARD trial has advanced to phase 3, with enrollment and dosing of approximately 50 participants targeted for completion in the first half of 2025 (now largely wrapped or wrapping up)
doi: 10.1002/acr2.70103
Improved Lipid Profiles: GLP-1 reduces triglycerides, LDL cholesterol, and improves HDL patterns independent of weight loss
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