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Description

The ability of probenecid to inhibit cAMP accumulation in GLP-1(2836)treated human caECs further supports our finding that GLP-1(2836) works through sAC to increase intracellular cAMP levels (Supplemental Figure 8C)

They don't establish causation

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In the SELECT trial, semaglutide reduced high-sensitivity C-reactive protein (an inflammatory marker) by 37.8%a reduction large enough to move patients from high cardiovascular risk (greater than 3 mg/dL) to intermediate risk (1-3 mg/dL)