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Clinical Trials and Safety Data GLP-1s have been studied in large-scale trials for over a decade
GLP-1RA treatment reduces fat mass and alleviates liver inflammation in db/db mice We next examined its impact on peripheral adiposity and liver
Stopping the medication can result in weight regain
Similar to selective GLP-1RAs, slowing of gastric emptying is greatest with the initial dose of tirzepatide, with this effect diminishing over time [15]
With this weight regain without re-building muscle, further insulin resistance can leave the patient worse off with a condition called sarcopenic obesity
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