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Over the past years, numerous ligands (for example, NBQX, NS102, NS3763, LY382884, LY377770, GYKI53655, UBP296, UBP301) with varying potency and selectivity have been synthesized to modulate AMPARs and KARs, several of which exhibit neuroprotective properties and beneficial effects in preclinical models of stroke, myocardial infarction, and brain injury (Matute, 2010)

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