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Lack of research is a problem here too, Al-Aly emphasized: The best evidence of this hypothetical effect is a preprint study that found that mice sought out their exercise wheel less after being injected with semaglutide

Obesity changes your muscle 'engine type': Excess weight shifts muscle fiber composition, reducing efficient, fat-burning Type I fibers and increasing less efficient, fatigue-prone Type IIx fibers, worsening metabolic flexibility