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Sumithran, also an endocrinologist at Alfred Health, has heard anecdotal reports of reductions in drinking and smoking in people on semaglutide, but has not encountered this in her own patients

Chromatin immunoprecipitation (ChIP) demonstrated increased occupancy of H2AX and decreased occupancy of all three acetylation marks at DSBs in both IDH1 inhibitor-treated and TMLHE-knockdown cells (Fig