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Nutrient Deficiency and Emerging Gut Microbiome Risks Even if individuals are aware of the physiological impact of food items, they may justify nutrient deficient food choices due to the GLP-1 RA-induced prolonged fasting periods

However, unlike our expectations, a synergistic effect of SGLT2 inhibitor and DPP-4 inhibitor use was not observed in these clinical trials, which could be attributed, at least partially, to the opposite action on glucagon secretion by the two classes of drugs

The glucagon component may affect hepatic metabolism, energy expenditure and the mobilisation of stored energy

Among their mechanisms is reducing the speed at which food progresses from the stomach into the small intestines

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