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252 Noncanonical Notch signaling, in contrast, can function independently of ligand stimulation or involve nontraditional intracellular mediators
The pivotal clinical trials that led to FDA approvalincluding the SUSTAIN trials for diabetes management and the STEP trials for weight managementdid not identify dry mouth as a statistically significant adverse event occurring at notably higher rates in semaglutide-treated patients compared to placebo groups
These renal protective mechanisms establish GLP-1 receptor agonists as preferred treatments for diabetes care in individuals with varying degrees of kidney damage, with evidence endorsing their use down to an eGFR of 15 mL/min/1.73m2 for specific medications