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Use of liraglutide 3mg daily in patients with obesity without diabetes was associated with nausea in 40.2% compared to 14.7% in the placebo (68)
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Participants received either weekly semaglutide injections or placebo injections for 32 weeks
This study was stopped early due to the frequency and magnitude of the elevation in ALT in the treatment group relative to controls, although none of the participants expressed symptoms of liver disease
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Early signals may appear first: appetite, satiety, nausea, bowel-pattern changes, and scale movement can show up before the formal trial endpoints, especially during dose escalation
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