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Vitamin K 2 has been shown to directly activate PXR in osteoblasts in culture leading to the induced expression of osteoblast-specific genes and increased collagen synthesis

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The coenzyme NADPH differs from nicotinamide adenine dinucleotide (NADH) only by the presence of a phosphate group on one of the ribose units

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therefore, using new needles with each administration will prevent contamination and potential infection at the injection site