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Its safety profile has specifically been demonstrated in pediatric populations, where it has been FDA-approved and used without significant adverse outcomes [12, 13]
Hai Y, Fan R, Zhao T, Lin R, Zhuang J, Deng A, et al
Tight junctions between intestinal epithelial cells restrict paracellular transport to molecules with radii well below those of therapeutic peptides, while transcellular transport favors lipophilic small molecules rather than hydrophilic macromolecules (Lundquist and Artursson, 2016)
Studies and clinical experience suggest weight regain is common if treatment stops and lifestyle changes aren't maintained
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