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GLP-1RAs can modulate inflammatory responses by affecting GLP-1Rs present on immune cells such as macrophages, monocytes, and lymphocytes

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GLP-1 medication can impact the bodys release of dopamine, making the sweet treats that you might have pursued for that delicious dopamine rush less rewarding

However, during the initial weeks particularly around dose increases mild fatigue is not uncommon and may be related to reduced caloric intake or the body adapting to altered metabolism