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This data supports our behavioural analysis that activating GLP-1R by its agonist liraglutide plays a major role in relieving CM-related hyperalgesia
They mimic the hormone GLP-1 (glucagon-like peptide-1) , which plays an important role in appetite regulation
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The most common side effects are nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, which may be particularly troublesome for fibromyalgia patients who often experience irritable bowel syndrome
Studies on animals have shown that GLP-1 receptor agonists might have protective effects on the brain and other nerve cells
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