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Importantly, it is the NRF2-KEAP1 interaction that creates a sensitive intracellular sensor system for oxidative stress, that can also be manipulated by electrophiles

FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)

What if your BMI is too low

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