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Cocaine- and amphetamine-regulated transcript (CART) and POMC are both neuropeptide proteins that are involved in energy regulation in the hypothalamus.[ref] CART causes suppression of appetite through leptin and this is also probably why cocaine and methamphetamine both cause appetite suppression

It Complements Semaglutide's Appetite Suppression The Mediterranean diet helps control appetite in two ways: with fiber and by triggering a hormonal response

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