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Trientine diHClide is another common copper chelator used for treating Wilson's disease (132), which can selectively bind Cu2+ ions to improve mitochondrial function in patients with hypertrophic cardiomyopathy (73), as well as restore mitochondrial function and normalize myocardial expression and enzymatic activity of proteins involved in energy metabolism among diabetic patients (133)

doi: 10.3892/or.2015.4476 218 HeWYuSWangLHeMCaoXLiYet al

Topical formulations have also demonstrated measurable effects on pigmentation

Senai Aksoy Sources Xu Y, Nisenblat V, Lu C, et al

Tissue healing takes time regardless of intervention support