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The signaling pathways activated by endogenous GLP-1 and GLP-1RAs also differ based on their concentrations
Neitemeier et al
The activated JNK [phospho-c-Jun N-terminal kinase (p-JNK)] combines with its target SH3 domain-binding protein (Sab) on the mitochondrial membrane, leading to a self-sustaining activation circuit of ROS production and JNK activation, which eventually leads to the opening of mitochondrial membrane permeability transition pore (MPT) [61]
Tranquilli AL, Bezzeccheri V, Giannubilo SR, Scagnoli C, Mazzanti L, Garzetti GG
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