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once stress disrupts the homeostasis, damage to the Golgi structure decreases APT2 contact with the Golgi, which leads to retention of palmitoylated NLRP3 in the Golgi and overactivation of the inflammasome (72)
With fewer spikes and crashes, cravings calm down and choices feel easier
Explain to patients receiving JANUMET in combination with these medications the risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development [see Warnings and Precautions (5.6)]
Additional risks include diabetic retinopathy complications (particularly with semaglutide in patients with pre-existing retinopathy), acute kidney injury (especially with volume depletion from gastrointestinal effects), and rare cases of intestinal obstruction or ileus
Fiber supplements, adequate water intake, and regular physical activity address most cases
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