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2021, doi:10.3389/fendo.2021.721135 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)

Drugs are studied and approved for certain uses

However, it can sometimes cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, especially when starting treatment or increasing the dose

The mechanism involves both vasoconstriction, where cold temperatures narrow blood vessels and slow medication dispersal, and direct tissue irritation from the temperature differential