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Learn more about Water Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier
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At baseline and at 2-, 4-, 6-, and 8 weeks, skin hydration (by a skin capacitance meter) and skin elasticity (by a cutometer) were quantified
In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required
Clinical studies show it can lead to elevated homocysteine and methylmalonic acid levels, markers associated with increased risk of type 2 diabetes and cardiovascular diseases
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