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Mechanical cues also activate Notch signaling in drug-resistant tumors

This may include: Taking prescribed antiemetics if recommended by your provider for significant nausea Elevating the head of the bed if reflux symptoms occur Avoiding trigger foods that worsen GI symptoms Ensuring adequate hydration throughout the day (but limiting fluids close to bedtime) Discussing temporary dose reduction or slower titration if GI symptoms are severe Monitor and prevent hypoglycemia

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The lack of GSH in the apo structure most likely reflects a relatively fast off-rate, leading to its loss during extensive purification