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In this 40-week study, 1879 patients were randomly assigned, in a 1:1:1:1 ratio, to receive tirzepatide at a dose of 5 mg, 10 mg, or 15 mg or semaglutide at a dose of 1 mg per week

The Peptide Problem: Why Oral GLP-1 Was So Difficult Glucagon-like peptide-1 is a 30-amino-acid incretin hormone secreted by enteroendocrine L-cells in the distal small intestine in response to nutrient ingestion

Some individuals experience reduced efficacy over time, requiring dose increases to maintain suppression of appetite and metabolic effects

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You might administer both peptides at the same time, or introduce one first and then the other after a set period