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Feck has played a major role in DOCS Education's growth as a leading provider of dental continuing education
Lancet 378 , 771784 (2011)
Short-chain fatty acids (SFCAs) like acetate, butyrate and propionate, derived from host microbial fermentation of non-digestible carbohydrates, transduce signals through GPCR to promote anti-inflammatory cytokines (IL-10, IL-18) and Treg responses [198, 199] These SCFAs also suppress pro-inflammatory histone deacetylase (HDAC), NF-B and nitric oxide production, thus diminishing oxidative stress-induced epithelial cell apoptosis, and exerting a protective effect on colonic and cardiac health [199]
For a molecule to cross passively, it generally needs three things: small size (under 500 Da), moderate lipophilicity (fat-solubility), and no permanent charge
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