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The benefits extend beyond weight loss, with GLP-1 also shown to reduce the risk of cardiovascular events such as coronary artery disease and strokes, as well as prevent and improve type 2 diabetes
GLP-1RA or dual GIP/GLP-1RA added to basal insulin provides a relevant weight reduction compared to basal insulin titration with a rigorous intention-to-treat approach ( weight = -3.95 kg, 95% CI -5.1, -2.79, I 2 96%)
Wang W, Volkow ND, Wang L, et al
Although the difference in the incidence of MACE between GLP-1 RA and comparators failed to show statistical significance (Mantel-Haenzel odds ratio, 0.78
29 , 12611273.e6 (2019)
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