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In the cell-free GCLC enzymatic assay, BSO inhibited the activity of GCLC with an IC50 of 570 nM [95% confidence interval (CI) 429757 nM
"Growth hormone secretagogues: history, mechanism of action, and clinical development." JCSM Rapid Communications
doi: 10.1038/s41413-022-00198-w 125 DedeADTrovasGChronopoulosETriantafyllopoulosIKDontasIPapaioannouNet al
Valproic acid is contraindicated in patients with known hypersensitivity to the drug [seeWarnings and Precautions (5.12)]
On the other hand, topical GHK-Cu is recognized as a safe peptide to use topically, with clinical studies demonstrating its support of skin health and tested specifically as ways to improve aging skin
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